So many confusing terms ...
Some certain diabetes medications have established themselves almost as “miracle cures” for rapid weight loss and are therefore used by both diabetics and non-diabetics for weight reduction.
Have you also been gripped by curiosity? Once you get into the subject, you often come across names like Ozempic and Wegovy or other diabetes or weight loss medications. You may wonder what a drug class is and how it relates to GLP-1 receptor agonists, and why that should even matter to you.
With all these different terms, it is often difficult to understand the connections between them and most importantly the effects of these medicines on your own body.
But no worries – it’s actually not that difficult.
Even after having some basic knowledge, it’s often difficult to understand how these terms are connected to one another.
You might have to look up almost every phrase to understand them, which often might make you give up on your search.
We would like to answer all these questions and explain the meaning of each term so that you don’t feel lost in this jungle of words.
Let’s Simplify the Terms You Encounter Every Day.
A class of drugs is a group of medicines that are alike. They work in the same way, have a similar chemical structure, and treat the same conditions. For diabetes management and weight loss, various classes of drugs are being used. Among the most common are GLP-1 receptor agonists, SGLT2 inhibitors, and DPP-4 inhibitors.
Or in simple terms: Gut hormone imitation with an “I’ve already eaten” signal
GLP-1 receptor agonists are a type of medicine that is currently getting a lot of attention in the news. This drug lowers blood sugar and reduces appetite by mimicking the natural hormone GLP-1, which is released by the gut after eating.
GLP-1 receptor agonists are a group of medicines currently receiving a lot of media attention. These drugs lower blood sugar levels and reduce appetite by mimicking the natural hormone GLP-1, which is released in the gut after eating.
The receptors for this hormone, GLP-1, are located in the brain. The hormone binds to these receptors in order to exert its effects in the body.
An agonist is a substance that binds to a cell’s receptor and sends signals. These signals are transmitted into the interior of the cell. Such an agonist can be a natural hormone or a synthetic version like the mimicked GLP-1 hormone. And the signal sent by the GLP-1 hormone can be, for example: “I’ve already eaten.”
The medication “tells” your brain that you’ve eaten — even if you haven’t. Since you don’t feel hungry, you end up eating less overall. And just like that, you lose weight.
Or in simple terms: Super-filter in the kidneys with a stop signal — “You, sugar, are getting flushed out of the body.”
Sodium-glucose cotransporter-2 inhibitors = SGLT2 inhibitors are a type of pill.
They are not an appetite suppressant, but a way for the kidneys to stop the release of sugar back into the blood. This means that the extra sugar is passed out of the body in the urine, which lowers the blood sugar level.
This medicine can also help you lose weight and lower your blood pressure.
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A more detailed explanation:
Sodium-glucose co-transporter 2 inhibitors (SGLT2 inhibitors) are not appetite suppressants, but rather medications that lower blood sugar levels. Normally, sugar and other useful substances are reabsorbed by the kidneys and returned to the bloodstream, while waste products are excreted through the urine. SGLT2 inhibitors act like a filter, sending a stop signal to the body that blocks the reabsorption of sugar into the blood. Instead, the sugar is excreted in the urine. This lowers blood sugar levels.
However, since the body still needs energy and relies on blood sugar for it, it has to retrieve sugar (glucose) from its energy reserves — glycogen and fat. Fat is broken down in the process, which leads to weight loss.
In simpler terms:
You can think of the effect of SGLT2 inhibitors as similar to a microscopic filter:
Imagine you have a container filled with sugar water. In our example, you pour the sugar water through the filter, and the filter only lets the water through, while the sugar stays behind in the container and is then discarded.
SGLT2 inhibitors work like this filter in our body, ensuring that most of the sugar is excreted through the urine and doesn’t re-enter the bloodstream.
Or in simple terms: Enzyme blocker that allows natural GLP-1 to be produced.
DPP-4 inhibitors are pills that lower blood sugar for people with type 2 diabetes.
Those are also no hunger suppression pills. They block (hence the name “inhibitor”) an enzyme called DPP-4, which breaks down special hormones called incretins.
These incretins aid the body in producing more insulin and reduce blood sugar levels after meals.
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A more detailed explanation:
Or in simple terms: enzyme blockers that allow natural GLP-1 to be produced.
DPP-4 inhibitors are medications that lower blood sugar in people with type 2 diabetes. These medications only indirectly suppress hunger.
Inhibitor means: blocker/inhibitor/preventer.
DPP-4 is an enzyme that normally breaks down GLP-1 — and another hormone called GIP.
DPP-4 is found in the endothelium (the thin layer lining the inside of blood vessels) of many organs, as well as in the blood, and is also connected to T-lymphocytes of the immune system.
So, DPP-4 inhibitors block the enzyme called DPP-4, allowing the body to produce more of its own natural GLP-1. As we remember: one of the signals of the GLP-1 hormone might be, “I’ve already eaten.”
DPP-4 inhibitors only increase the body’s own gut hormones GLP-1 and GIP — and, as a result, insulin secretion in the pancreas — when carbohydrates have been consumed beforehand. Since more insulin is then released to reduce blood sugar, blood sugar levels decrease accordingly.
Sugar that is not used in the blood — for example, for muscle activity or other energy needs — remains in the bloodstream. Normally, excess sugar is taken up by the body’s cells and either stored long-term as fat with the help of insulin, or short-term as glycogen in the liver and muscles. However, if too much sugar remains in the blood over time, it can have harmful effects on the body.
In people with type 2 diabetes, insulin regulation often doesn’t work properly. Due to insulin resistance, sugar stays in the blood instead of entering the cells. This leads to high blood sugar levels, which over time can damage blood vessels, nerves, and organs.
Now that we know about different drug classes for diabetes medication or weight control medication, let’s talk about active ingredients.
The active ingredient is the chemical in a medicine that makes it work. It interacts with the body to give the medicine its effects.
Popular weight control medicines like Ozempic, Wegovy, Mounjaro, and Saxenda use three different types of active ingredients.
Active ingredients belonging to GLP-1 receptor agonists: Semaglutide
Active ingredients belonging to GLP-1 receptor agonists: Semaglutide
Active ingredients belonging to GLP-1 receptor agonists: Tirzepatide
Active ingredients belonging to GLP-1 receptor agonists:Liraglutide
Tirzepatide, Semaglutide, and Liraglutide are popular active ingredients which are used for type 2 diabetes and sometimes for weight loss.
They belong to the class of drugs known as GLP-1 receptor agonists, but Tirzepatide also targets GIP receptors. GIP is gastric inhibitory peptide. GIP binds to GIP receptors on the cell membrane of the so-called beta cells of the pancreas and thus promotes the release of insulin.
Each weight control medicine has its own benefits and risks. By understanding these, you can use the drugs more effectively and reduce potential problems.
Note: All information shared in this article is for general understanding of various diabetes medicines and weight control medicines. Always, consult with your doctor to find out, which medicine is best suited for your individual needs.
Tirzepatide vs Semaglutide vs Liraglutide : what does each active ingredient do?
Class: GLP-1 receptor agonist
Mechanism: Semaglutide mimics the effects of (GLP-1) hormone. It enhances insulin secretion, reduces glucagon secretion, slows gastric emptying, and curbs appetite.
Administration: Available as a once-weekly subcutaneous injection or as an oral tablet taken daily. The weekly form is more common for weight loss and diabetes management.
Uses: Primarily used for the management of type 2 diabetes and weight management in adults with obesity or overweight.
Efficacy:
Semaglutide is highly effective in reducing HbA1c levels, often comparable to or slightly less effective than Tirzepatide but more effective than Liraglutide.
Semaglutide also promotes significant weight loss, with patients typically losing around 15% of their body weight.
Additional benefits: Has demonstrated significant cardiovascular benefits in reducing major adverse cardiovascular events in patients with type 2 diabetes.
Side Effects: Known for its strong efficacy but also associated with gastrointestinal side effects, particularly when starting the medication. Nausea, vomiting, diarrhea, and constipation are frequent complaints after using the drug. Serious side effects can include pancreatitis and diabetic retinopathy.
Conclusion
Semaglutide is highly effective, especially for weight loss, and has an oral form (tablet), which can be more convenient for some patients.
Class: GLP-1 receptor agonist
Mechanism: Liraglutide works similarly to Semaglutide by imitating GLP-1 to enhance insulin secretion, suppress glucagon, slow gastric emptying, and reduce appetite.
Administration: Available as a daily subcutaneous injection. Typically, treatment begins with a lower dose that is gradually increased to minimize gastrointestinal side effects.
Uses: It is used to manage type 2 diabetes, help with weight loss, and reduce heart disease risk in patients with type 2 diabetes.
Efficacy:
Liraglutide effectively lowers HbA1c levels but generally to a lesser extent than both Tirzepatide and Semaglutide. It is also effective for weight loss, though typically less so than Semaglutide and Tirzepatide. Patients often experience around 5-10% weight loss.
Side Effects Nausea, vomiting, diarrhea, and constipation are frequent complaints after using the drug. Serious side effects can include pancreatitis and gallbladder disease. Similar side effect profile but might cause fewer gastrointestinal issues compared to the higher doses of Semaglutide and Tirzepatide.
Conclusion:
Liraglutide is effective but generally not as strong as the other two options. However, it may have slightly fewer gastrointestinal side effects. Even though it causes less weight loss, it also has milder side effects, which makes it a popular choice.
Class: Dual GLP-1/GIP receptor agonist
Mechanism: Tirzepatide acts on both GLP-1 and glucose-dependent insulinotropic polypeptide (GIP) receptors, enhancing insulin secretion, reducing glucagon levels, slowing gastric emptying, and decreasing appetite.
Administration: Available as a once-weekly subcutaneous injection.
Uses: Primarily used for the management of type 2 diabetes and weight management in adults with obesity or overweight.
Efficacy: Shown to significantly reduce HbA1c levels and promote substantial weight loss, often greater than that achieved with GLP-1 receptor agonists alone. Tirzepatide has demonstrated greater weight loss effects than both Semaglutide and Liraglutide, with some studies showing average weight loss of up to 22.5%.
Additional Benefits: Tirzepatide shows promising cardiovascular benefits, but long-term studies are still ongoing.
Side Effects: Generally well-tolerated, but can cause more significant gastrointestinal discomfort at higher doses. Nausea, vomiting, diarrhea, and constipation are frequent complaints after using the drug. Serious side effects can include pancreatitis and gallbladder disease.
Conclusion:
Tirzepatide is very effective for both blood sugar control and weight loss, often better than Semaglutide and Liraglutide, but it might cause more gastrointestinal issues.
Now that we understand how these terms are connected, let’s take a closer look at different medicines which are used as diabetes medication and weight control medicines. Understanding the correct proper storage conditions can help you maximize the benefits of the treatments, because the medicine maintains its efficacy. Additionally, it can minimize side effects, which are detailed in the PMI (patient medication information).
GLP-1 receptor agonists lower blood sugar and reduce appetite by mimicking the natural hormone GLP-1 released after eating. (``I have already eaten`` -signal)
Frequency
Once weekly
Storage
Unused Ozempic pens must be refrigerated.
Once opened, they can be refrigerated or stored at room temperature (between 59°F to 86°F or 15°C to 30°C) for 56 days.
Frequency
Storage
Wegovy can be stored at room temperature (46°F to 86°F) for up to 28 days in an unopened carton.
After opening, store it below 30°C (86°F).
Frequency
Storage
Keep your unused pen(s) in the refrigerator at 36° to 46° F (2°C to 8°C). The pen you currently use can be kept at room temperature (up to 59° to 86°F) (15°C to 30°C) for up to 30 days.
Frequency
Storage
Store between 36 F to 46 F (2 C to 8 C).
Mounjaro can be exposed to temperatures up to 86 F (30 C), for no more than 21 days.
Super-filter in the kidneys with a stop signal — “You, sugar, are getting flushed out of the body.”
Frequency
Once daily (10mg)
May increase up to 25mg daily
Storage
Store JARDIANCE at room temperature between (20°C to 25°C)
Frequency
Storage
Enzyme blocker that allows natural GLP-1 to be produced.
Frequency
Once daily (100mg)
Storage
Frequency
Storage
Frequency
Storage
Frequency
Storage
Research shows that about 30% of people using semaglutide for weight loss are non-diabetic. They take it under brand names like Wegovy and Ozempic, which are mainly for diabetes but are now also used to treat obesity.
Ozempic is one of the most talked-about drugs today. The reason is: it was originally created to help people manage diabetes. This means it helps control blood sugar levels for people with type 2 diabetes.
But Ozempic has another use that has become very popular: weight loss.
Even though it wasn’t originally approved for this purpose, many people use it off-label to help them lose weight. Studies have shown that semaglutide, the active ingredient in Ozempic, can result in significant weight loss when used in higher doses along with lifestyle changes.
So, while Ozempic is a well-known diabetes medication, it’s also gaining fame among non-diabetics for helping them with weight loss. This has made it a hot topic in the media.
Understanding Off-Label Use
Off-label use means using a medicine for a reason that is not officially approved by a regulatory authority like FDA.
For example, if a drug is meant to help with diabetes, it might also be used to help with weight loss, even though it wasn’t originally approved for that purpose.
Ozempic is viewed as one of the most popular weight loss medications available. However, there are also several alternatives to Ozempic that offer similar benefits.
We want to provide you with information about these alternatives so you can make an informed decision together with your doctor about which medication might best meet your needs.
Rybelsus: Rybelsus is a pill approved by the FDA that contains Semaglutide. Unlike other diabetes drugs that need to be injected, Rybelsus is taken as a tablet. This makes it easier for people who don’t want injections. It’s active ingredient Semaglutide helps control blood sugar and aids in weight loss by acting like GLP-1 receptor agonists.
Trulicity: Trulicity is a shot used to help control blood sugar in people with type 2 diabetes. It works like a natural hormone called GLP-1, which helps manage insulin and blood sugar levels. Trulicity also lowers the risk of heart disease in people with type 2 diabetes, making it useful for both blood sugar control and heart health.
Mounjaro: Mounjaro is a medicine for people with type 2 diabetes to help control their blood sugar. It works by improving the body’s insulin sensitivity and regulating glucose levels. This helps keep blood sugar levels in check and prevents diabetes-related problems. Mounjaro can also help with weight loss, which is good for managing diabetes.
Wegovy
Wegovy is the first drug approved by the FDA for long-term weight management. It is given as an injection under the skin.Wegovy works by mimicking GLP-1 receptor agonists, which target the parts of the brain that control appetite and food intake. This helps people feel less hungry and eat less, making it easier to manage their weight.
Saxenda
Saxenda is a medicine for adults and some children with obesity. It works by copying a hormone that controls appetite, helping people eat less and lose weight. But, Saxenda has a warning about a possible risk of thyroid cancer. In studies, some people using Saxenda developed thyroid tumors, including cancer. So, patients and doctors need to talk about this risk and watch for thyroid problems during treatment.
Zepbound
Zepbound is part of a weight loss plan that also includes diet, exercise, and lifestyle changes. It works by affecting hormones and body pathways that control hunger and metabolism. This helps people feel less hungry and more full. Like other weight loss drugs, Zepbound can have side effects, so it’s important for patients to talk with their doctor to see if Zepbound is right for them.
This website is not meant to provide medical advice, diagnosis, or provide treatment. It is for informational and educational purpose only. We would like to encourage you to seek your primary care provider should you have medical concerns. The information provided on this website is not meant to be a substitute for a visit with a healthcare provider. Any comments made about specific products, medicines or treatment plans are not meant to diagnose, cure or prevent disease.